It hit me while checking out Fred Saberhagen’s fantasy classic The Book of Swords: This should be a video game.
The Book of Swords has a great out-of-the-box premise. “For a game the gods have given the world twelve Swords of Power so that they might be amused as the nations battle for their possession. But Vulcan the Smith has had his own little joke: the Swords can kill the gods themselves.”
I would play the heck out of that game. Even more so if there were dual storylines where you could play through as a human hunting down a God-slaying sword, or a God collecting the swords before all the humans can kill you.