I run the science fiction & fantasy section at the University Book Store in Seattle, WA. I also work in the children’s books area, and try to keep my boss sane.
Our store was founded in 1900 as a student co-op in a cloak room on the campus, and grew from there. We are still proudly independent, and sell more “real” (ie non-textbooks) books than any other college bookstore in the US. We carry the largest selection of SF (new books at least) in the Pacific Northwest, and I would argue we would stack up against any US bookstore. Our author reading series is decades old, covering authors from all genres and affiliations. We try in particular to corner the market on SF authors, and have given many of them their first public event.